Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4567765..4568575 Replicon chromosome
Accession NZ_LR890726
Organism Klebsiella pneumoniae isolate INF102-sc-2279897

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag JMX38_RS22445 Protein ID WP_004178461.1
Coordinates 4567765..4568298 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A483I2M4
Locus tag JMX38_RS22450 Protein ID WP_004222378.1
Coordinates 4568309..4568575 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX38_RS22440 4566596..4567717 + 1122 WP_002887282.1 cupin domain-containing protein -
JMX38_RS22445 4567765..4568298 - 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
JMX38_RS22450 4568309..4568575 - 267 WP_004222378.1 DUF1778 domain-containing protein Antitoxin
JMX38_RS22455 4568678..4570111 - 1434 WP_004222374.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX38_RS22460 4570101..4570784 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX38_RS22465 4570956..4572341 + 1386 WP_004222371.1 efflux transporter outer membrane subunit -
JMX38_RS22470 4572359..4572703 + 345 WP_004222368.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T291988 WP_004178461.1 NZ_LR890726:c4568298-4567765 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9969.44 Da        Isoelectric Point: 10.1757

>AT291988 WP_004222378.1 NZ_LR890726:c4568575-4568309 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLSEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A483I2M4

References