Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2531630..2533218 Replicon chromosome
Accession NZ_LR890726
Organism Klebsiella pneumoniae isolate INF102-sc-2279897

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX38_RS12485 Protein ID WP_040148030.1
Coordinates 2531630..2532952 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX38_RS12490 Protein ID WP_002904790.1
Coordinates 2532952..2533218 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX38_RS12470 2526686..2529187 + 2502 WP_064147278.1 fimbrial biogenesis outer membrane usher protein -
JMX38_RS12475 2529175..2530179 + 1005 WP_040216236.1 type 1 fimbrial protein -
JMX38_RS12480 2530321..2531613 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX38_RS12485 2531630..2532952 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX38_RS12490 2532952..2533218 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX38_RS12495 2533483..2533809 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX38_RS12500 2533806..2534306 - 501 WP_064147279.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX38_RS12505 2534284..2535663 - 1380 WP_004184021.1 purine permease -
JMX38_RS12510 2536009..2537163 + 1155 WP_064168621.1 FAD-dependent urate hydroxylase HpxO -
JMX38_RS12515 2537144..2538067 - 924 WP_064147281.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T291985 WP_040148030.1 NZ_LR890726:c2532952-2531630 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291985 WP_002904790.1 NZ_LR890726:c2533218-2532952 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References