Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 208309..209048 Replicon chromosome
Accession NZ_LR890726
Organism Klebsiella pneumoniae isolate INF102-sc-2279897

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMX38_RS01035 Protein ID WP_021312536.1
Coordinates 208563..209048 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMX38_RS01030 Protein ID WP_003026799.1
Coordinates 208309..208575 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX38_RS01015 203813..205882 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
JMX38_RS01020 206178..207547 + 1370 WP_087661561.1 IS3 family transposase -
JMX38_RS01025 207748..208176 + 429 WP_004901287.1 GFA family protein -
JMX38_RS01030 208309..208575 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMX38_RS01035 208563..209048 + 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
JMX38_RS01040 209373..210419 - 1047 WP_004173931.1 IS481-like element ISKpn28 family transposase -
JMX38_RS01045 210493..210645 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
JMX38_RS01050 210724..211836 + 1113 WP_001300563.1 IS4-like element IS421 family transposase -
JMX38_RS01055 212296..213915 + 1620 WP_064147680.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 206822..211999 5177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T291978 WP_021312536.1 NZ_LR890726:208563-209048 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291978 WP_003026799.1 NZ_LR890726:208309-208575 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References