Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 53536..54272 Replicon plasmid 2
Accession NZ_LR890723
Organism Klebsiella pneumoniae isolate KSB1_1H

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag JMW72_RS25510 Protein ID WP_003026803.1
Coordinates 53790..54272 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW72_RS25505 Protein ID WP_003026799.1
Coordinates 53536..53802 (+) Length 89 a.a.

Genomic Context


JMW72_RS25470JMW72_RS25475JMW72_RS25480JMW72_RS25485JMW72_RS25490JMW72_RS25495JMW72_RS25505JMW72_RS25510JMW72_RS25515JMW72_RS25520JMW72_RS25460JMW72_RS25465JMW72_RS25500JMW72_RS25525JMW72_RS25530
Location: 50856..51104 (249 bp)
Type: Others
Protein ID: WP_019725036.1
Location: 51101..51673 (573 bp)
Type: Others
Protein ID: WP_015065504.1
Location: 51704..52198 (495 bp)
Type: Others
Protein ID: WP_009310053.1
Location: 52242..52610 (369 bp)
Type: Others
Protein ID: WP_015065502.1
Location: 52644..52847 (204 bp)
Type: Others
Protein ID: WP_019725040.1
Location: 52861..53091 (231 bp)
Type: Others
Protein ID: WP_019725034.1
Location: 53536..53802 (267 bp)
Type: Antitoxin
Protein ID: WP_003026799.1
Location: 53790..54272 (483 bp)
Type: Toxin
Protein ID: WP_003026803.1
Location: 54480..55826 (1347 bp)
Type: Others
Protein ID: WP_077253535.1
Location: 55875..56270 (396 bp)
Type: Others
Protein ID: WP_004143398.1
Location: 49736..50098 (363 bp)
Type: Others
Protein ID: WP_004152100.1
Location: 50148..50498 (351 bp)
Type: Others
Protein ID: WP_004152101.1
Location: 53135..53329 (195 bp)
Type: Others
Protein ID: WP_019725033.1
Location: 56418..57672 (1255 bp)
Type: Others
Protein ID: Protein_58
Location: 57760..58722 (963 bp)
Type: Others
Protein ID: WP_004152113.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JMW72_RS2546049736..50098-363WP_004152100.1arsenite efflux transporter metallochaperone ArsD-
JMW72_RS2546550148..50498-351WP_004152101.1As(III)-sensing metalloregulatory transcriptional repressor ArsR-
JMW72_RS2547050856..51104+249WP_019725036.1hypothetical protein-
JMW72_RS2547551101..51673+573WP_015065504.1hypothetical protein-
JMW72_RS2548051704..52198+495WP_009310053.1hypothetical protein-
JMW72_RS2548552242..52610+369WP_015065502.1hypothetical protein-
JMW72_RS2549052644..52847+204WP_019725040.1hemolysin expression modulator Hha-
JMW72_RS2549552861..53091+231WP_019725034.1hypothetical protein-
JMW72_RS2550053135..53329-195WP_019725033.1hypothetical protein-
JMW72_RS2550553536..53802+267WP_003026799.1DUF1778 domain-containing proteinAntitoxin
JMW72_RS2551053790..54272+483WP_003026803.1GNAT family N-acetyltransferaseToxin
JMW72_RS2551554480..55826+1347WP_077253535.1ISNCY family transposase-
JMW72_RS2552055875..56270+396WP_004143398.1helix-turn-helix domain-containing protein-
JMW72_RS2552556418..57672-1255Protein_58IS3 family transposase-
JMW72_RS2553057760..58722-963WP_004152113.1M48 family metalloprotease-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidqnrB1 / dfrA14 / blaCTX-M-15 / aac(6')-Ib-cr / blaOXA-1-1..225937225937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(45-149)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T291976 WP_003026803.1 NZ_LR890723:53790-54272 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291976 WP_003026799.1 NZ_LR890723:53536-53802 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0J2GNW6


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1Q8YL66

References