Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 837694..838171 Replicon chromosome
Accession NC_020564
Organism Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAI2T2_RS04030 Protein ID WP_000052076.1
Coordinates 837694..837882 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAI2T2_RS04035 Protein ID WP_001059690.1
Coordinates 837911..838171 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAI2T2_RS04000 833688..834209 + 522 WP_000824485.1 hypothetical protein -
SAI2T2_RS04005 834550..835236 + 687 WP_000141557.1 thermonuclease family protein -
SAI2T2_RS04010 835593..835793 + 201 WP_001059082.1 cold-shock protein -
SAI2T2_RS04015 836285..836503 - 219 WP_000005886.1 hypothetical protein -
SAI2T2_RS04020 836565..836849 - 285 WP_001004399.1 hypothetical protein -
SAI2T2_RS04025 836937..837506 - 570 WP_001106654.1 hypothetical protein -
SAI2T2_RS04030 837694..837882 - 189 WP_000052076.1 hypothetical protein Toxin
SAI2T2_RS04035 837911..838171 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAI2T2_RS04040 838512..838715 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAI2T2_RS04045 838712..838948 - 237 WP_000349581.1 hypothetical protein -
SAI2T2_RS04050 839173..839754 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAI2T2_RS04055 839827..840444 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAI2T2_RS04060 840599..841093 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAI2T2_RS04065 841492..841914 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAI2T2_RS04070 842062..842778 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)

Antitoxin

Toxin YoeB

(7-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29197 WP_000052076.1 NC_020564:c837882-837694 [Staphylococcus aureus subsp. aureus ST228]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29197 NC_020564:c837882-837694 [Staphylococcus aureus subsp. aureus ST228]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29197 WP_001059690.1 NC_020564:c838171-837911 [Staphylococcus aureus subsp. aureus ST228]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29197 NC_020564:c838171-837911 [Staphylococcus aureus subsp. aureus ST228]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References