Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781530..782187 Replicon chromosome
Accession NZ_LR890722
Organism Klebsiella pneumoniae isolate KSB1_1H

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW72_RS03870 Protein ID WP_002916310.1
Coordinates 781777..782187 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW72_RS03865 Protein ID WP_002916312.1
Coordinates 781530..781796 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW72_RS03840 776738..778171 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
JMW72_RS03845 778290..779018 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMW72_RS03850 779068..779379 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMW72_RS03855 779543..780202 + 660 WP_002916317.1 hemolysin III family protein -
JMW72_RS03860 780301..781284 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMW72_RS03865 781530..781796 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW72_RS03870 781777..782187 + 411 WP_002916310.1 protein YgfX Toxin
JMW72_RS03875 782194..782715 - 522 WP_004144730.1 flavodoxin FldB -
JMW72_RS03880 782816..783712 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW72_RS03885 783735..784448 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW72_RS03890 784454..786187 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291964 WP_002916310.1 NZ_LR890722:781777-782187 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291964 WP_002916312.1 NZ_LR890722:781530-781796 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References