Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1781..2328 Replicon plasmid 3
Accession NZ_LR890721
Organism Klebsiella pneumoniae isolate INF161-sc-2280013

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JMW82_RS25780 Protein ID WP_025750222.1
Coordinates 2047..2328 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag JMW82_RS25775 Protein ID WP_000079928.1
Coordinates 1781..2050 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW82_RS25770 1..873 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
JMW82_RS25775 1781..2050 + 270 WP_000079928.1 hypothetical protein Antitoxin
JMW82_RS25780 2047..2328 + 282 WP_025750222.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW82_RS25785 2842..3459 - 618 WP_025750220.1 hypothetical protein -
JMW82_RS25790 3768..4464 - 697 Protein_4 IS1 family transposase -
JMW82_RS25795 4698..6017 - 1320 WP_160470889.1 cation:dicarboxylase symporter family transporter -
JMW82_RS25800 6229..6925 + 697 Protein_6 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..89062 89062


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10875.53 Da        Isoelectric Point: 8.4615

>T291961 WP_025750222.1 NZ_LR890721:2047-2328 [Klebsiella pneumoniae]
MIEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT291961 WP_000079928.1 NZ_LR890721:1781-2050 [Klebsiella pneumoniae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References