Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Xre
Location 94944..95643 Replicon plasmid 2
Accession NZ_LR890720
Organism Klebsiella pneumoniae isolate INF161-sc-2280013

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMW82_RS25725 Protein ID WP_074193184.1
Coordinates 95254..95643 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMW82_RS25720 Protein ID WP_201519678.1
Coordinates 94944..95261 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW82_RS25690 90598..91221 - 624 WP_201519677.1 TetR/AcrR family transcriptional regulator -
JMW82_RS25695 91801..92025 + 225 Protein_100 hypothetical protein -
JMW82_RS25700 92101..92721 + 621 WP_201519696.1 TauD/TfdA family dioxygenase -
JMW82_RS25705 92757..93545 + 789 WP_201519697.1 TSUP family transporter -
JMW82_RS25710 93547..94119 + 573 WP_064168490.1 GNAT family N-acetyltransferase -
JMW82_RS25715 94301..94639 + 339 WP_135687034.1 cupin domain-containing protein -
JMW82_RS25720 94944..95261 - 318 WP_201519678.1 helix-turn-helix domain-containing protein Antitoxin
JMW82_RS25725 95254..95643 - 390 WP_074193184.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW82_RS25730 95890..96990 + 1101 WP_201519679.1 NADH:flavin oxidoreductase/NADH oxidase -
JMW82_RS25735 97195..97980 - 786 Protein_108 DUF4113 domain-containing protein -
JMW82_RS25740 97980..98315 - 336 WP_201519680.1 peptidase -
JMW82_RS25745 98405..98830 + 426 Protein_110 translesion error-prone DNA polymerase V autoproteolytic subunit -
JMW82_RS25750 98830..100101 + 1272 Protein_111 Y-family DNA polymerase -
JMW82_RS25755 100180..100248 + 69 Protein_112 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..103373 103373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(3-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-90)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14243.40 Da        Isoelectric Point: 4.9626

>T291960 WP_074193184.1 NZ_LR890720:c95643-95254 [Klebsiella pneumoniae]
VGVYLTPEFEEDRQSARISNAILCKAAKAIFSGLPGDPLGKFTYKKRLGLPGVGARDGARSIVFFNDGENVFFFDMYLKS
ALSKKKGRELEPDEIDAYCNIAKDFIAMSPAVIKQLLADKELIEVTCDD

Download         Length: 390 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11584.48 Da        Isoelectric Point: 11.1898

>AT291960 WP_201519678.1 NZ_LR890720:c95261-94944 [Klebsiella pneumoniae]
MTERLKRIQGMAARYNKFGVVKDETVAAIDAAVAARTIPAVRAMTGSQIKEVRTRYNMSQAALAKTTGMSVESVSKWERN
ESRPNKAALRIINIIDTKGPQVFMA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References