Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2636674..2638262 Replicon chromosome
Accession NZ_LR890719
Organism Klebsiella pneumoniae isolate INF161-sc-2280013

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag JMW82_RS12980 Protein ID WP_016946382.1
Coordinates 2636674..2637996 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW82_RS12985 Protein ID WP_002904790.1
Coordinates 2637996..2638262 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW82_RS12965 2631730..2634231 + 2502 WP_023282574.1 fimbrial biogenesis outer membrane usher protein -
JMW82_RS12970 2634219..2635223 + 1005 WP_016946380.1 type 1 fimbrial protein -
JMW82_RS12975 2635365..2636657 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
JMW82_RS12980 2636674..2637996 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW82_RS12985 2637996..2638262 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW82_RS12990 2638649..2638975 - 327 WP_004215084.1 hydroxyisourate hydrolase -
JMW82_RS12995 2638972..2639472 - 501 WP_023282573.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW82_RS13000 2639450..2640829 - 1380 WP_004184021.1 purine permease -
JMW82_RS13005 2641175..2642329 + 1155 WP_023282572.1 FAD-dependent urate hydroxylase HpxO -
JMW82_RS13010 2642310..2643233 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T291953 WP_016946382.1 NZ_LR890719:c2637996-2636674 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291953 WP_002904790.1 NZ_LR890719:c2638262-2637996 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References