Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1772..2319 Replicon plasmid 2
Accession NZ_LR890715
Organism Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)


Gene name parE Uniprot ID A0A4Y1YQH8
Locus tag JMW19_RS24905 Protein ID WP_012881118.1
Coordinates 2038..2319 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E2GHF7
Locus tag JMW19_RS24900 Protein ID WP_012881119.1
Coordinates 1772..2041 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW19_RS24890 1..858 + 858 WP_000130646.1 incFII family plasmid replication initiator RepA -
JMW19_RS24895 1559..1717 + 159 WP_032142560.1 hypothetical protein -
JMW19_RS24900 1772..2041 + 270 WP_012881119.1 ABC transporter ATPase Antitoxin
JMW19_RS24905 2038..2319 + 282 WP_012881118.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW19_RS24910 2365..3213 + 849 WP_012881117.1 3'-5' exonuclease -
JMW19_RS24915 3330..3812 + 483 WP_001311056.1 hypothetical protein -
JMW19_RS24920 3841..5325 - 1485 WP_016240487.1 IS5 family transposase -
JMW19_RS24925 5405..6280 - 876 WP_001617865.1 class A extended-spectrum beta-lactamase CTX-M-14 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..70350 70350
- flank IS/Tn blaCTX-M-14 - 5405..7792 2387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10875.53 Da        Isoelectric Point: 8.4615

>T291946 WP_012881118.1 NZ_LR890715:2038-2319 [Escherichia coli]
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10206.54 Da        Isoelectric Point: 8.8735

>AT291946 WP_012881119.1 NZ_LR890715:1772-2041 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1YQH8

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y1YSD8

References