Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4730671..4731168 Replicon chromosome
Accession NZ_LR890714
Organism Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag JMW19_RS22620 Protein ID WP_001173343.1
Coordinates 4730671..4730844 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag JMW19_RS22625 Protein ID WP_000398619.1
Coordinates 4730872..4731168 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW19_RS22610 4727341..4728798 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
JMW19_RS22615 4729035..4730552 + 1518 WP_001550472.1 lysine--tRNA ligase -
JMW19_RS22620 4730671..4730844 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
JMW19_RS22625 4730872..4731168 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
JMW19_RS22630 4731397..4731669 - 273 WP_000405647.1 N-acetyltransferase -
JMW19_RS22635 4731681..4731911 - 231 WP_001550470.1 (4Fe-4S)-binding protein -
JMW19_RS22640 4732091..4733722 + 1632 WP_001216477.1 sensor histidine kinase -
JMW19_RS22645 4733719..4734438 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T291944 WP_001173343.1 NZ_LR890714:c4730844-4730671 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT291944 WP_000398619.1 NZ_LR890714:c4731168-4730872 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References