291941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4510585..4511405 Replicon chromosome
Accession NZ_LR890714
Organism Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)


Gene name yjhX Uniprot ID A0A0V9MKL8
Locus tag JMW19_RS21505 Protein ID WP_001550554.1
Coordinates 4510585..4510842 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag JMW19_RS21510 Protein ID WP_001519303.1
Coordinates 4510854..4511405 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW19_RS21485 4505871..4506977 + 1107 WP_001519308.1 N-acetylneuraminate epimerase -
JMW19_RS21490 4507042..4508022 + 981 WP_001519307.1 transposase -
JMW19_RS21495 4508605..4509846 - 1242 Protein_4207 DNA helicase -
JMW19_RS21500 4509909..4510208 + 300 WP_001519304.1 GNAT family N-acetyltransferase -
JMW19_RS21505 4510585..4510842 + 258 WP_001550554.1 hypothetical protein Toxin
JMW19_RS21510 4510854..4511405 + 552 WP_001519303.1 N-acetyltransferase Antitoxin
JMW19_RS21515 4511457..4511618 + 162 WP_201523978.1 hypothetical protein -
JMW19_RS21520 4511655..4512203 + 549 WP_001519301.1 hypothetical protein -
JMW19_RS21525 4512330..4512590 + 261 WP_000084876.1 hypothetical protein -
JMW19_RS21530 4512628..4512744 + 117 Protein_4214 VOC family protein -
JMW19_RS21535 4512989..4514110 + 1122 WP_000010833.1 M42 family metallopeptidase -
JMW19_RS21540 4514107..4514385 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JMW19_RS21545 4514397..4515710 + 1314 WP_001519300.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4501995..4511618 9623


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9744.33 Da        Isoelectric Point: 11.0090

>T291941 WP_001550554.1 NZ_LR890714:4510585-4510842 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20463.61 Da        Isoelectric Point: 6.8758

>AT291941 WP_001519303.1 NZ_LR890714:4510854-4511405 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9MKL8

Antitoxin

Source ID Structure

References