Detailed information of TA system TA291937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4067728..4069417
• Replicon: chromosome
• Accession: NZ_LR890714
• Organism: Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: V0Z9M0
• Locus tag: JMW19_RS19400
• Protein ID: WP_000365809.1
• Coordinates: 4067728..4068648 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JMW19_RS19405
• Protein ID: WP_001550661.1
• Coordinates: 4068635..4069417 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW19_RS19385	4063818..4064945	-	1128	WP_001550663.1	MFS transporter	-
JMW19_RS19390	4065087..4066145	-	1059	WP_122987197.1	alpha/beta hydrolase	-
JMW19_RS19395	4066410..4067294	+	885	WP_001119037.1	LysR family transcriptional regulator	-
JMW19_RS19400	4067728..4068648	-	921	WP_000365809.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW19_RS19405	4068635..4069417	-	783	WP_001550661.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JMW19_RS19410	4069733..4072942	+	3210	WP_201523974.1	RNA-directed DNA polymerase	-
JMW19_RS19415	4073103..4073243	+	141	WP_001308408.1	ash family protein	-
JMW19_RS19420	4073289..4073759	+	471	WP_000201185.1	hypothetical protein	-
JMW19_RS19425	4073756..4073858	+	103	Protein_3804	helix-turn-helix domain-containing protein	-
JMW19_RS19430	4073950..4074108	+	159	Protein_3805	integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-247)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34571.01 Da
• Isoelectric Point: 7.2649

>T291937 WP_000365809.1 NZ_LR890714:c4068648-4067728 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29191.43 Da
• Isoelectric Point: 8.9059

>AT291937 WP_001550661.1 NZ_LR890714:c4069417-4068635 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: V0Z9M0