Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2735267..2735905 Replicon chromosome
Accession NZ_LR890714
Organism Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag JMW19_RS12950 Protein ID WP_000813795.1
Coordinates 2735729..2735905 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMW19_RS12945 Protein ID WP_076797675.1
Coordinates 2735267..2735683 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW19_RS12925 2730419..2731360 - 942 WP_001251315.1 ABC transporter permease -
JMW19_RS12930 2731361..2732374 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
JMW19_RS12935 2732392..2733537 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
JMW19_RS12940 2733782..2735188 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
JMW19_RS12945 2735267..2735683 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMW19_RS12950 2735729..2735905 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMW19_RS12955 2736127..2736357 + 231 WP_023910283.1 YncJ family protein -
JMW19_RS12960 2736449..2738410 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMW19_RS12965 2738483..2739019 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
JMW19_RS12970 2739072..2740283 + 1212 WP_071591517.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T291933 WP_000813795.1 NZ_LR890714:c2735905-2735729 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT291933 WP_076797675.1 NZ_LR890714:c2735683-2735267 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References