291920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72599..73434 Replicon chromosome
Accession NZ_LR890714
Organism Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)


Gene name yeeV Uniprot ID B1LDL9
Locus tag JMW19_RS00305 Protein ID WP_001094444.1
Coordinates 72599..72976 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag JMW19_RS00310 Protein ID WP_001285607.1
Coordinates 73066..73434 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW19_RS00275 67948..68871 - 924 WP_000535949.1 carboxylate/amino acid/amine transporter -
JMW19_RS00280 68982..70166 - 1185 WP_001172876.1 sugar efflux transporter -
JMW19_RS00285 70594..70776 - 183 WP_177309578.1 hypothetical protein -
JMW19_RS00290 70960..71802 - 843 WP_000036706.1 DUF4942 domain-containing protein -
JMW19_RS00295 71899..72096 - 198 WP_000839266.1 DUF957 domain-containing protein -
JMW19_RS00300 72114..72602 - 489 WP_000761680.1 hypothetical protein -
JMW19_RS00305 72599..72976 - 378 WP_001094444.1 TA system toxin CbtA family protein Toxin
JMW19_RS00310 73066..73434 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JMW19_RS00315 73514..73735 - 222 WP_000692350.1 DUF987 domain-containing protein -
JMW19_RS00320 73822..74298 - 477 WP_053289525.1 RadC family protein -
JMW19_RS00325 74314..74793 - 480 WP_000844100.1 antirestriction protein -
JMW19_RS00330 74875..75693 - 819 WP_072649142.1 DUF945 domain-containing protein -
JMW19_RS00335 75783..76016 - 234 WP_001278287.1 DUF905 family protein -
JMW19_RS00340 76022..76699 - 678 WP_001097301.1 hypothetical protein -
JMW19_RS00345 76847..77527 - 681 Protein_68 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14087.02 Da        Isoelectric Point: 7.3523

>T291920 WP_001094444.1 NZ_LR890714:c72976-72599 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT291920 WP_001285607.1 NZ_LR890714:c73434-73066 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1LDL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References