Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4716363..4716879 Replicon chromosome
Accession NZ_LR890710
Organism Klebsiella pneumoniae isolate KSB2_9B

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMX55_RS22990 Protein ID WP_023317444.1
Coordinates 4716363..4716647 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX55_RS22995 Protein ID WP_002886901.1
Coordinates 4716637..4716879 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX55_RS22965 4711758..4712066 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMX55_RS22970 4712151..4712324 + 174 WP_032408826.1 hypothetical protein -
JMX55_RS22975 4712327..4713070 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX55_RS22980 4713427..4715565 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX55_RS22985 4715895..4716359 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX55_RS22990 4716363..4716647 - 285 WP_023317444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX55_RS22995 4716637..4716879 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX55_RS23000 4716957..4718867 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMX55_RS23005 4718890..4720044 - 1155 WP_002886900.1 lactonase family protein -
JMX55_RS23010 4720111..4720851 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11151.99 Da        Isoelectric Point: 10.3787

>T291916 WP_023317444.1 NZ_LR890710:c4716647-4716363 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291916 WP_002886901.1 NZ_LR890710:c4716879-4716637 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References