Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2613500..2615088 Replicon chromosome
Accession NZ_LR890710
Organism Klebsiella pneumoniae isolate KSB2_9B

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX55_RS12835 Protein ID WP_087825728.1
Coordinates 2613500..2614822 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX55_RS12840 Protein ID WP_002904790.1
Coordinates 2614822..2615088 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX55_RS12820 2608557..2611058 + 2502 WP_032436339.1 fimbrial biogenesis outer membrane usher protein -
JMX55_RS12825 2611046..2612050 + 1005 WP_032436338.1 type 1 fimbrial protein -
JMX55_RS12830 2612191..2613483 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX55_RS12835 2613500..2614822 - 1323 WP_087825728.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX55_RS12840 2614822..2615088 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX55_RS12845 2615475..2615801 - 327 WP_032436336.1 hydroxyisourate hydrolase -
JMX55_RS12850 2615798..2616298 - 501 WP_032436335.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX55_RS12855 2616276..2617655 - 1380 Protein_2516 purine permease -
JMX55_RS12860 2618001..2619155 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX55_RS12865 2619136..2620059 - 924 WP_032436334.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49134.45 Da        Isoelectric Point: 7.5617

>T291913 WP_087825728.1 NZ_LR890710:c2614822-2613500 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLVLARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291913 WP_002904790.1 NZ_LR890710:c2615088-2614822 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References