Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4351899..4352709 Replicon chromosome
Accession NZ_LR890702
Organism Klebsiella pneumoniae isolate INF305-sc-2280094

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag JMX64_RS21505 Protein ID WP_004178461.1
Coordinates 4352176..4352709 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMX64_RS21500 Protein ID WP_002887278.1
Coordinates 4351899..4352165 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX64_RS21480 4347771..4348115 - 345 WP_064162549.1 cation efflux system protein CusF -
JMX64_RS21485 4348133..4349518 - 1386 WP_064162550.1 efflux transporter outer membrane subunit -
JMX64_RS21490 4349690..4350373 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX64_RS21495 4350363..4351796 + 1434 WP_201624845.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX64_RS21500 4351899..4352165 + 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMX64_RS21505 4352176..4352709 + 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
JMX64_RS21510 4352757..4353878 - 1122 WP_004214138.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T291895 WP_004178461.1 NZ_LR890702:4352176-4352709 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291895 WP_002887278.1 NZ_LR890702:4351899-4352165 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References