291872

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4156651..4157171 Replicon chromosome
Accession NZ_LR890693
Organism Escherichia coli isolate MSB1_4E-sc-2280348

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag JMW23_RS20235 Protein ID WP_001160964.1
Coordinates 4156887..4157171 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag JMW23_RS20230 Protein ID WP_000125566.1
Coordinates 4156651..4156884 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW23_RS20205 4151724..4152011 + 288 WP_000203744.1 ferredoxin-like protein FixX -
JMW23_RS20210 4152070..4153401 + 1332 WP_001183209.1 MFS transporter -
JMW23_RS20215 4153509..4154039 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
JMW23_RS20220 4154032..4155894 + 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
JMW23_RS20225 4156086..4156565 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
JMW23_RS20230 4156651..4156884 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JMW23_RS20235 4156887..4157171 + 285 WP_001160964.1 CcdB family protein Toxin
JMW23_RS20240 4157198..4158046 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
JMW23_RS20245 4158053..4158430 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
JMW23_RS20250 4158433..4159254 - 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
JMW23_RS20255 4159251..4160240 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
JMW23_RS20260 4160240..4161526 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T291872 WP_001160964.1 NZ_LR890693:4156887-4157171 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT291872 WP_000125566.1 NZ_LR890693:4156651-4156884 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References