291865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2937138..2937938 Replicon chromosome
Accession NZ_LR890693
Organism Escherichia coli isolate MSB1_4E-sc-2280348

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag JMW23_RS14585 Protein ID WP_000342452.1
Coordinates 2937138..2937665 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag JMW23_RS14590 Protein ID WP_001277107.1
Coordinates 2937672..2937938 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW23_RS14560 2932214..2932981 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JMW23_RS14565 2932978..2934255 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
JMW23_RS14570 2934252..2935178 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JMW23_RS14575 2935226..2936335 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
JMW23_RS14580 2936758..2937141 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
JMW23_RS14585 2937138..2937665 - 528 WP_000342452.1 GNAT family N-acetyltransferase Toxin
JMW23_RS14590 2937672..2937938 - 267 WP_001277107.1 DUF1778 domain-containing protein Antitoxin
JMW23_RS14595 2938087..2939190 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
JMW23_RS14600 2939461..2940315 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
JMW23_RS14605 2940560..2941618 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
JMW23_RS14610 2941611..2942279 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T291865 WP_000342452.1 NZ_LR890693:c2937665-2937138 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT291865 WP_001277107.1 NZ_LR890693:c2937938-2937672 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References