Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2260271..2260925 Replicon chromosome
Accession NZ_LR890693
Organism Escherichia coli isolate MSB1_4E-sc-2280348

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag JMW23_RS11200 Protein ID WP_000244765.1
Coordinates 2260271..2260678 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag JMW23_RS11205 Protein ID WP_000354050.1
Coordinates 2260659..2260925 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW23_RS11180 2256228..2257961 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
JMW23_RS11185 2257967..2258677 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW23_RS11190 2258702..2259598 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JMW23_RS11195 2259710..2260231 + 522 WP_001055874.1 flavodoxin FldB -
JMW23_RS11200 2260271..2260678 - 408 WP_000244765.1 protein YgfX Toxin
JMW23_RS11205 2260659..2260925 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
JMW23_RS11210 2261168..2262148 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
JMW23_RS11215 2262225..2262884 - 660 WP_000250275.1 hemolysin III family protein -
JMW23_RS11220 2263048..2263359 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
JMW23_RS11225 2263404..2264837 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T291861 WP_000244765.1 NZ_LR890693:c2260678-2260271 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT291861 WP_000354050.1 NZ_LR890693:c2260925-2260659 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References