Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 200737..201263 Replicon plasmid 2
Accession NZ_LR890692
Organism Klebsiella pneumoniae isolate INF119-sc-2279930

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMW99_RS26105 Protein ID WP_000323025.1
Coordinates 200737..201024 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMW99_RS26110 Protein ID WP_000534858.1
Coordinates 201024..201263 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW99_RS26060 195888..196208 - 321 WP_004152720.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMW99_RS26065 196289..196513 - 225 WP_004152719.1 hypothetical protein -
JMW99_RS26070 196524..196736 - 213 WP_004182070.1 hypothetical protein -
JMW99_RS26075 196797..197153 - 357 WP_004152717.1 hypothetical protein -
JMW99_RS26080 197789..198139 - 351 WP_004182068.1 hypothetical protein -
JMW99_RS26085 198136..198408 - 273 WP_004182067.1 hypothetical protein -
JMW99_RS26090 199104..199265 - 162 WP_004118124.1 type I toxin-antitoxin system Hok family toxin -
JMW99_RS26095 199335..200393 + 1059 WP_201524158.1 IS481 family transposase -
JMW99_RS26100 200335..200853 + 519 WP_135724303.1 integrase core domain-containing protein -
JMW99_RS26105 200737..201024 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMW99_RS26110 201024..201263 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMW99_RS26115 201526..202449 - 924 WP_020277922.1 cation diffusion facilitator family transporter -
JMW99_RS26120 202649..203221 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
JMW99_RS26125 203697..204242 - 546 Protein_211 IS110 family transposase -
JMW99_RS26135 205843..206217 - 375 WP_004182064.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 199335..205639 6304
- inside Conjugative plasmid - - 1..233443 233443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T291849 WP_000323025.1 NZ_LR890692:c201024-200737 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT291849 WP_000534858.1 NZ_LR890692:c201263-201024 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References