Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 97930..98452 Replicon plasmid 2
Accession NZ_LR890692
Organism Klebsiella pneumoniae isolate INF119-sc-2279930

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMW99_RS25545 Protein ID WP_004187019.1
Coordinates 98168..98452 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMW99_RS25540 Protein ID WP_004187025.1
Coordinates 97930..98178 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW99_RS25515 93218..94012 - 795 WP_004187050.1 tetratricopeptide repeat protein -
JMW99_RS25520 94071..95417 - 1347 WP_077254682.1 ISNCY family transposase -
JMW99_RS25525 95626..96108 - 483 WP_004098919.1 GNAT family N-acetyltransferase -
JMW99_RS25530 96096..96362 - 267 WP_032415032.1 DUF1778 domain-containing protein -
JMW99_RS25535 96708..97676 + 969 WP_000654811.1 IS5 family transposase -
JMW99_RS25540 97930..98178 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMW99_RS25545 98168..98452 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW99_RS25550 98468..98620 - 153 WP_122985329.1 hypothetical protein -
JMW99_RS25560 99852..100229 + 378 WP_004114613.1 IS66 family insertion sequence hypothetical protein -
JMW99_RS25565 100226..100573 + 348 WP_004114612.1 IS66 family insertion sequence element accessory protein TnpB -
JMW99_RS25570 100623..102160 + 1538 Protein_100 IS66 family transposase -
JMW99_RS25575 102198..102575 + 378 Protein_101 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..233443 233443
- inside IScluster/Tn - - 94071..102575 8504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T291848 WP_004187019.1 NZ_LR890692:98168-98452 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT291848 WP_004187025.1 NZ_LR890692:97930-98178 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References