Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 95626..96362 Replicon plasmid 2
Accession NZ_LR890692
Organism Klebsiella pneumoniae isolate INF119-sc-2279930

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag JMW99_RS25525 Protein ID WP_004098919.1
Coordinates 95626..96108 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JMW99_RS25530 Protein ID WP_032415032.1
Coordinates 96096..96362 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW99_RS25510 91527..93179 + 1653 WP_032415028.1 hypothetical protein -
JMW99_RS25515 93218..94012 - 795 WP_004187050.1 tetratricopeptide repeat protein -
JMW99_RS25520 94071..95417 - 1347 WP_077254682.1 ISNCY family transposase -
JMW99_RS25525 95626..96108 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
JMW99_RS25530 96096..96362 - 267 WP_032415032.1 DUF1778 domain-containing protein Antitoxin
JMW99_RS25535 96708..97676 + 969 WP_000654811.1 IS5 family transposase -
JMW99_RS25540 97930..98178 + 249 WP_004187025.1 plasmid stabilization protein -
JMW99_RS25545 98168..98452 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMW99_RS25550 98468..98620 - 153 WP_122985329.1 hypothetical protein -
JMW99_RS25560 99852..100229 + 378 WP_004114613.1 IS66 family insertion sequence hypothetical protein -
JMW99_RS25565 100226..100573 + 348 WP_004114612.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..233443 233443
- inside IScluster/Tn - - 94071..102575 8504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T291847 WP_004098919.1 NZ_LR890692:c96108-95626 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.53 Da        Isoelectric Point: 4.5141

>AT291847 WP_032415032.1 NZ_LR890692:c96362-96096 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure

References