Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4784816..4786497 Replicon chromosome
Accession NZ_LR890691
Organism Klebsiella pneumoniae isolate INF119-sc-2279930

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag JMW99_RS23240 Protein ID WP_004146663.1
Coordinates 4784816..4785733 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMW99_RS23245 Protein ID WP_004177809.1
Coordinates 4785739..4786497 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW99_RS23220 4780122..4781642 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
JMW99_RS23225 4781639..4782637 + 999 WP_012737175.1 ribose ABC transporter permease -
JMW99_RS23230 4782668..4783609 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
JMW99_RS23235 4783684..4784691 + 1008 WP_023302355.1 carbohydrate kinase family protein -
JMW99_RS23240 4784816..4785733 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMW99_RS23245 4785739..4786497 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMW99_RS23250 4786583..4787311 - 729 WP_002885152.1 response regulator transcription factor -
JMW99_RS23255 4787584..4789731 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
JMW99_RS23260 4789961..4790647 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T291845 WP_004146663.1 NZ_LR890691:c4785733-4784816 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT291845 WP_004177809.1 NZ_LR890691:c4786497-4785739 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB J2XCI1


Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References