Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3912094..3912713 | Replicon | chromosome |
Accession | NZ_LR890691 | ||
Organism | Klebsiella pneumoniae isolate INF119-sc-2279930 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | JMW99_RS19030 | Protein ID | WP_002892050.1 |
Coordinates | 3912495..3912713 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | JMW99_RS19025 | Protein ID | WP_002892066.1 |
Coordinates | 3912094..3912468 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMW99_RS19015 | 3907246..3908439 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
JMW99_RS19020 | 3908462..3911608 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
JMW99_RS19025 | 3912094..3912468 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
JMW99_RS19030 | 3912495..3912713 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
JMW99_RS19035 | 3912872..3913438 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
JMW99_RS19040 | 3913410..3913550 | - | 141 | WP_004147370.1 | hypothetical protein | - |
JMW99_RS19045 | 3913571..3914041 | + | 471 | WP_002892026.1 | YlaC family protein | - |
JMW99_RS19050 | 3914016..3915467 | - | 1452 | WP_023302231.1 | PLP-dependent aminotransferase family protein | - |
JMW99_RS19055 | 3915568..3916266 | + | 699 | WP_002892021.1 | GNAT family N-acetyltransferase | - |
JMW99_RS19060 | 3916263..3916403 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
JMW99_RS19065 | 3916403..3916666 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T291842 WP_002892050.1 NZ_LR890691:3912495-3912713 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT291842 WP_002892066.1 NZ_LR890691:3912094-3912468 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |