Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3912094..3912713 Replicon chromosome
Accession NZ_LR890691
Organism Klebsiella pneumoniae isolate INF119-sc-2279930

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JMW99_RS19030 Protein ID WP_002892050.1
Coordinates 3912495..3912713 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JMW99_RS19025 Protein ID WP_002892066.1
Coordinates 3912094..3912468 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW99_RS19015 3907246..3908439 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMW99_RS19020 3908462..3911608 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JMW99_RS19025 3912094..3912468 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JMW99_RS19030 3912495..3912713 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JMW99_RS19035 3912872..3913438 + 567 WP_002892030.1 maltose O-acetyltransferase -
JMW99_RS19040 3913410..3913550 - 141 WP_004147370.1 hypothetical protein -
JMW99_RS19045 3913571..3914041 + 471 WP_002892026.1 YlaC family protein -
JMW99_RS19050 3914016..3915467 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
JMW99_RS19055 3915568..3916266 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JMW99_RS19060 3916263..3916403 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JMW99_RS19065 3916403..3916666 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T291842 WP_002892050.1 NZ_LR890691:3912495-3912713 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT291842 WP_002892066.1 NZ_LR890691:3912094-3912468 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References