Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2594613..2596201 | Replicon | chromosome |
Accession | NZ_LR890691 | ||
Organism | Klebsiella pneumoniae isolate INF119-sc-2279930 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A486S9S0 |
Locus tag | JMW99_RS12610 | Protein ID | WP_023301940.1 |
Coordinates | 2594613..2595935 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JMW99_RS12615 | Protein ID | WP_024622638.1 |
Coordinates | 2595935..2596201 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMW99_RS12595 | 2589669..2592170 | + | 2502 | WP_201524154.1 | fimbrial biogenesis outer membrane usher protein | - |
JMW99_RS12600 | 2592158..2593162 | + | 1005 | WP_023301939.1 | type 1 fimbrial protein | - |
JMW99_RS12605 | 2593304..2594596 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
JMW99_RS12610 | 2594613..2595935 | - | 1323 | WP_023301940.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
JMW99_RS12615 | 2595935..2596201 | - | 267 | WP_024622638.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
JMW99_RS12620 | 2596466..2596792 | - | 327 | WP_004184023.1 | hydroxyisourate hydrolase | - |
JMW99_RS12625 | 2596789..2597289 | - | 501 | WP_004184022.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
JMW99_RS12630 | 2597267..2598646 | - | 1380 | WP_023301941.1 | purine permease | - |
JMW99_RS12635 | 2598992..2600146 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
JMW99_RS12640 | 2600127..2601050 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49185.49 Da Isoelectric Point: 7.5358
>T291840 WP_023301940.1 NZ_LR890691:c2595935-2594613 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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