Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2594613..2596201 Replicon chromosome
Accession NZ_LR890691
Organism Klebsiella pneumoniae isolate INF119-sc-2279930

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag JMW99_RS12610 Protein ID WP_023301940.1
Coordinates 2594613..2595935 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW99_RS12615 Protein ID WP_024622638.1
Coordinates 2595935..2596201 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW99_RS12595 2589669..2592170 + 2502 WP_201524154.1 fimbrial biogenesis outer membrane usher protein -
JMW99_RS12600 2592158..2593162 + 1005 WP_023301939.1 type 1 fimbrial protein -
JMW99_RS12605 2593304..2594596 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW99_RS12610 2594613..2595935 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW99_RS12615 2595935..2596201 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW99_RS12620 2596466..2596792 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JMW99_RS12625 2596789..2597289 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW99_RS12630 2597267..2598646 - 1380 WP_023301941.1 purine permease -
JMW99_RS12635 2598992..2600146 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW99_RS12640 2600127..2601050 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T291840 WP_023301940.1 NZ_LR890691:c2595935-2594613 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT291840 WP_024622638.1 NZ_LR890691:c2596201-2595935 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure

References