Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 148002..148753 Replicon plasmid 2
Accession NZ_LR890687
Organism Klebsiella pneumoniae isolate INF201-sc-2280069

Toxin (Protein)


Gene name ataT Uniprot ID A0A071LQ79
Locus tag JMX24_RS26295 Protein ID WP_036114515.1
Coordinates 148002..148484 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JMX24_RS26300 Protein ID WP_049095199.1
Coordinates 148475..148753 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX24_RS26275 144510..145913 + 1404 WP_201616449.1 glycoside hydrolase family 1 protein -
JMX24_RS26280 146005..146367 - 363 WP_117389542.1 type II toxin-antitoxin system VapC family toxin -
JMX24_RS26285 146526..146867 - 342 Protein_155 AAA family ATPase -
JMX24_RS26290 146945..147869 + 925 Protein_156 IS5 family transposase -
JMX24_RS26295 148002..148484 - 483 WP_036114515.1 GNAT family N-acetyltransferase Toxin
JMX24_RS26300 148475..148753 - 279 WP_049095199.1 DUF1778 domain-containing protein Antitoxin
JMX24_RS26305 148875..149087 - 213 WP_049095200.1 hypothetical protein -
JMX24_RS26310 149554..149880 - 327 WP_075209941.1 hypothetical protein -
JMX24_RS26315 149924..150034 + 111 Protein_161 glutathione ABC transporter permease GsiC -
JMX24_RS26320 150118..151788 - 1671 WP_032413257.1 AMP-binding protein -
JMX24_RS26325 151769..153034 - 1266 WP_048281137.1 MSMEG_0569 family flavin-dependent oxidoreductase -
JMX24_RS26330 153052..153342 - 291 WP_032413253.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..169772 169772
- flank IS/Tn - - 147054..147869 815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(3-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17694.45 Da        Isoelectric Point: 8.9130

>T291832 WP_036114515.1 NZ_LR890687:c148484-148002 [Klebsiella pneumoniae]
MGMRAPESLTSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWSGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10734.25 Da        Isoelectric Point: 4.5271

>AT291832 WP_049095199.1 NZ_LR890687:c148753-148475 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFETFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A071LQ79

Antitoxin

Source ID Structure

References