Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 24742..25652 Replicon plasmid 2
Accession NZ_LR890687
Organism Klebsiella pneumoniae isolate INF201-sc-2280069

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JMX24_RS25670 Protein ID WP_048984280.1
Coordinates 25182..25652 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JMX24_RS25665 Protein ID WP_004026357.1
Coordinates 24742..25185 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX24_RS25640 20525..20863 - 339 WP_049095046.1 hypothetical protein -
JMX24_RS25645 21062..21784 + 723 Protein_27 DUF969 domain-containing protein -
JMX24_RS25650 21781..22767 + 987 Protein_28 DUF979 domain-containing protein -
JMX24_RS25655 22777..23772 + 996 WP_049095045.1 DUF2891 domain-containing protein -
JMX24_RS25660 23933..24620 + 688 Protein_30 DUF4113 domain-containing protein -
JMX24_RS25665 24742..25185 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JMX24_RS25670 25182..25652 + 471 WP_048984280.1 RES family NAD+ phosphorylase Toxin
JMX24_RS25675 25763..26023 - 261 WP_004026352.1 hypothetical protein -
JMX24_RS25680 26532..27901 + 1370 WP_087661561.1 IS3 family transposase -
JMX24_RS25685 28102..28530 + 429 WP_004901287.1 GFA family protein -
JMX24_RS25690 28663..28929 + 267 WP_049095044.1 DUF1778 domain-containing protein -
JMX24_RS25695 28917..29402 + 486 WP_117389532.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..169772 169772
- inside IScluster/Tn - - 27176..31767 4591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17524.80 Da        Isoelectric Point: 4.7599

>T291830 WP_048984280.1 NZ_LR890687:25182-25652 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQHIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT291830 WP_004026357.1 NZ_LR890687:24742-25185 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References