Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2703961..2705549 Replicon chromosome
Accession NZ_LR890686
Organism Klebsiella pneumoniae isolate INF201-sc-2280069

Toxin (Protein)


Gene name hipA Uniprot ID A0A486MZ73
Locus tag JMX24_RS13150 Protein ID WP_009485244.1
Coordinates 2703961..2705283 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX24_RS13155 Protein ID WP_002904790.1
Coordinates 2705283..2705549 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX24_RS13135 2699017..2701518 + 2502 WP_009485242.1 fimbrial biogenesis outer membrane usher protein -
JMX24_RS13140 2701506..2702510 + 1005 WP_009485243.1 type 1 fimbrial protein -
JMX24_RS13145 2702652..2703944 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX24_RS13150 2703961..2705283 - 1323 WP_009485244.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX24_RS13155 2705283..2705549 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX24_RS13160 2705815..2706141 - 327 WP_009485245.1 hydroxyisourate hydrolase -
JMX24_RS13165 2706138..2706638 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX24_RS13170 2706616..2707995 - 1380 WP_004184021.1 purine permease -
JMX24_RS13175 2708341..2709495 + 1155 WP_009485247.1 FAD-dependent urate hydroxylase HpxO -
JMX24_RS13180 2709476..2710399 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49157.50 Da        Isoelectric Point: 7.5062

>T291824 WP_009485244.1 NZ_LR890686:c2705283-2703961 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291824 WP_002904790.1 NZ_LR890686:c2705549-2705283 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486MZ73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References