Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 58322..59079 Replicon plasmid 3
Accession NZ_LR890681
Organism Klebsiella pneumoniae isolate INF279-sc-2280202

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J4ZXV7
Locus tag JMX25_RS27600 Protein ID WP_029497408.1
Coordinates 58597..59079 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JMX25_RS27595 Protein ID WP_094645258.1
Coordinates 58322..58609 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX25_RS27565 53685..53877 - 193 Protein_61 MFS transporter -
JMX25_RS27570 53907..54884 + 978 WP_004196334.1 chromate resistance protein -
JMX25_RS27575 54841..56217 + 1377 WP_004196363.1 chromate efflux transporter -
JMX25_RS27580 56248..56937 - 690 WP_004196322.1 hypothetical protein -
JMX25_RS27585 56951..57688 - 738 WP_008460272.1 HupE/UreJ family protein -
JMX25_RS27590 57732..58097 - 366 WP_009651956.1 hypothetical protein -
JMX25_RS27595 58322..58609 + 288 WP_094645258.1 DUF1778 domain-containing protein Antitoxin
JMX25_RS27600 58597..59079 + 483 WP_029497408.1 GNAT family N-acetyltransferase Toxin
JMX25_RS27605 59476..60168 - 693 Protein_69 IS3-like element ISKpn38 family transposase -
JMX25_RS27610 60198..60554 - 357 Protein_70 transposase -
JMX25_RS27615 60588..62126 - 1539 WP_004196907.1 IS66-like element ISEc22 family transposase -
JMX25_RS27620 62175..62522 - 348 WP_004196919.1 IS66 family insertion sequence element accessory protein TnpB -
JMX25_RS27625 62519..62923 - 405 WP_004196883.1 IS66 family insertion sequence hypothetical protein -
JMX25_RS27630 63005..63853 - 849 Protein_74 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71104 71104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17599.34 Da        Isoelectric Point: 9.8719

>T291817 WP_029497408.1 NZ_LR890681:58597-59079 [Klebsiella pneumoniae]
VGRLTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLRLP

Download         Length: 483 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10955.66 Da        Isoelectric Point: 4.5141

>AT291817 WP_094645258.1 NZ_LR890681:58322-58609 [Klebsiella pneumoniae]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVVDD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZXV7

Antitoxin

Source ID Structure

References