Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2642390..2643978 Replicon chromosome
Accession NZ_LR890679
Organism Klebsiella pneumoniae isolate INF279-sc-2280202

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag JMX25_RS13020 Protein ID WP_004176197.1
Coordinates 2642390..2643712 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX25_RS13025 Protein ID WP_032417111.1
Coordinates 2643712..2643978 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX25_RS13005 2637446..2639947 + 2502 WP_016831617.1 fimbrial biogenesis outer membrane usher protein -
JMX25_RS13010 2639935..2640939 + 1005 WP_004176196.1 type 1 fimbrial protein -
JMX25_RS13015 2641081..2642373 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX25_RS13020 2642390..2643712 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX25_RS13025 2643712..2643978 - 267 WP_032417111.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX25_RS13030 2644243..2644569 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX25_RS13035 2644566..2645066 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX25_RS13040 2645044..2646423 - 1380 WP_032429500.1 purine permease -
JMX25_RS13045 2646769..2647923 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX25_RS13050 2647904..2648827 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2443621..2677645 234024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T291808 WP_004176197.1 NZ_LR890679:c2643712-2642390 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9926.32 Da        Isoelectric Point: 8.5912

>AT291808 WP_032417111.1 NZ_LR890679:c2643978-2643712 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure

References