Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 736952..737709 Replicon chromosome
Accession NZ_LR890679
Organism Klebsiella pneumoniae isolate INF279-sc-2280202

Toxin (Protein)


Gene name tacT Uniprot ID A0A1D8JMF4
Locus tag JMX25_RS03650 Protein ID WP_044159004.1
Coordinates 737227..737709 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1D8JMH3
Locus tag JMX25_RS03645 Protein ID WP_007372584.1
Coordinates 736952..737236 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX25_RS03625 732344..733066 + 723 WP_013095151.1 TIGR03761 family integrating conjugative element protein -
JMX25_RS03630 733084..735096 + 2013 WP_044159002.1 DNA topoisomerase III -
JMX25_RS03635 735729..736220 + 492 WP_007372582.1 DUF3577 domain-containing protein -
JMX25_RS03640 736296..736796 + 501 WP_007372583.1 single-stranded DNA-binding protein -
JMX25_RS03645 736952..737236 + 285 WP_007372584.1 DUF1778 domain-containing protein Antitoxin
JMX25_RS03650 737227..737709 + 483 WP_044159004.1 GNAT family N-acetyltransferase Toxin
JMX25_RS03655 737942..739228 + 1287 WP_013095156.1 TcpQ domain-containing protein -
JMX25_RS03660 739230..739673 + 444 WP_007372587.1 type IV pilus biogenesis protein PilM -
JMX25_RS03665 739693..741366 + 1674 WP_013095157.1 PilN family type IVB pilus formation outer membrane protein -
JMX25_RS03670 741369..742649 + 1281 WP_176682058.1 type 4b pilus protein PilO2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 724822..832258 107436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-146)

Antitoxin

Vibrio phage ICP1, Orf50

(1-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17693.32 Da        Isoelectric Point: 6.9570

>T291802 WP_044159004.1 NZ_LR890679:737227-737709 [Klebsiella pneumoniae]
MEINVTAPALLTEEHVLHSFDCGNAVLDDWLRRRALKNQHLNASRTFVICPEGTACVVGYYSLATGSVSHVDLSRSLRQN
MPDPVPVVLLGRLAVDVSTQGNNFGKWLLNDAVMRVSNLADQVGIKAIMVHAIDERAKAFYEYFGFVQSPVAANTLFYKI

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11078.63 Da        Isoelectric Point: 8.5684

>AT291802 WP_007372584.1 NZ_LR890679:736952-737236 [Klebsiella pneumoniae]
MQTPVRKSVRDKQINIRATDEERAVIDYAASLVNKNRTDFIIERAVHEAQNIILDQRVFVLDDARYQAFIRQLEAPVQNV
EGRQRLMDVKPEWK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JMF4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8JMH3

References