Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 61612..62348 Replicon plasmid 3
Accession NZ_LR890671
Organism Klebsiella pneumoniae isolate INF321-sc-2280120

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag JMW44_RS25770 Protein ID WP_003026803.1
Coordinates 61866..62348 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW44_RS25765 Protein ID WP_003026799.1
Coordinates 61612..61878 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW44_RS25745 58311..58619 - 309 WP_017896554.1 hypothetical protein -
JMW44_RS25755 60338..60886 + 549 WP_001567366.1 thioredoxin fold domain-containing protein -
JMW44_RS25760 60933..61367 + 435 WP_001567367.1 cell envelope integrity protein TolA -
JMW44_RS25765 61612..61878 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMW44_RS25770 61866..62348 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
JMW44_RS25780 64146..64907 - 762 WP_201507409.1 DUF945 domain-containing protein -
JMW44_RS25785 65735..66148 - 414 WP_021312979.1 helix-turn-helix domain-containing protein -
JMW44_RS25790 66149..66427 - 279 WP_004152721.1 helix-turn-helix domain-containing protein -
JMW44_RS25795 66417..66737 - 321 WP_004152720.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMW44_RS25800 66818..67042 - 225 WP_014343499.1 hypothetical protein -
JMW44_RS25805 67053..67265 - 213 WP_019706020.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..115932 115932
- inside IScluster/Tn - - 54993..64101 9108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T291797 WP_003026803.1 NZ_LR890671:61866-62348 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291797 WP_003026799.1 NZ_LR890671:61612-61878 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References