Detailed information of TA system TA291792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4691731..4693412
• Replicon: chromosome
• Accession: NZ_LR890669
• Organism: Klebsiella pneumoniae isolate INF321-sc-2280120

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JMW44_RS22860
• Protein ID: WP_064179395.1
• Coordinates: 4691731..4692648 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JMW44_RS22865
• Protein ID: WP_004177809.1
• Coordinates: 4692654..4693412 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW44_RS22840	4687037..4688557	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JMW44_RS22845	4688554..4689552	+	999	WP_012737175.1	ribose ABC transporter permease	-
JMW44_RS22850	4689583..4690524	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMW44_RS22855	4690599..4691606	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
JMW44_RS22860	4691731..4692648	-	918	WP_064179395.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW44_RS22865	4692654..4693412	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW44_RS22870	4693498..4694226	-	729	WP_004177810.1	response regulator transcription factor	-
JMW44_RS22875	4694499..4696646	+	2148	WP_128317850.1	formate dehydrogenase subunit alpha	-
JMW44_RS22880	4696876..4697562	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34633.01 Da
• Isoelectric Point: 5.0955

>T291792 WP_064179395.1 NZ_LR890669:c4692648-4691731 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALEGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT291792 WP_004177809.1 NZ_LR890669:c4693412-4692654 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05