Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 714020..714795 Replicon chromosome
Accession NZ_LR890669
Organism Klebsiella pneumoniae isolate INF321-sc-2280120

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag JMW44_RS03560 Protein ID WP_004889762.1
Coordinates 714310..714795 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW44_RS03555 Protein ID WP_004150912.1
Coordinates 714020..714313 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW44_RS03535 709228..709830 - 603 WP_004174410.1 short chain dehydrogenase -
JMW44_RS03540 709928..710839 + 912 WP_021314148.1 LysR family transcriptional regulator -
JMW44_RS03545 710840..711988 - 1149 WP_064179254.1 PLP-dependent aspartate aminotransferase family protein -
JMW44_RS03550 711999..713375 - 1377 WP_004181304.1 cystathionine beta-synthase -
JMW44_RS03555 714020..714313 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW44_RS03560 714310..714795 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
JMW44_RS03565 714974..715426 - 453 WP_080816334.1 hypothetical protein -
JMW44_RS03570 715931..718216 - 2286 WP_064179256.1 hypothetical protein -
JMW44_RS03575 718345..718582 - 238 Protein_702 hypothetical protein -
JMW44_RS03580 718616..719584 + 969 WP_077255423.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 718661..719584 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T291781 WP_004889762.1 NZ_LR890669:714310-714795 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291781 WP_004150912.1 NZ_LR890669:714020-714313 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References