Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4756940..4757456 Replicon chromosome
Accession NZ_LR890665
Organism Klebsiella pneumoniae isolate INF065-sc-2279980

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JMX32_RS23065 Protein ID WP_004178374.1
Coordinates 4756940..4757224 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX32_RS23070 Protein ID WP_002886901.1
Coordinates 4757214..4757456 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX32_RS23040 4752336..4752644 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JMX32_RS23045 4752729..4752902 + 174 WP_004222159.1 hypothetical protein -
JMX32_RS23050 4752905..4753648 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX32_RS23055 4754005..4756143 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
JMX32_RS23060 4756472..4756936 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX32_RS23065 4756940..4757224 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX32_RS23070 4757214..4757456 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX32_RS23075 4757534..4759444 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMX32_RS23080 4759467..4760621 - 1155 WP_004146773.1 lactonase family protein -
JMX32_RS23085 4760688..4761428 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T291770 WP_004178374.1 NZ_LR890665:c4757224-4756940 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291770 WP_002886901.1 NZ_LR890665:c4757456-4757214 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References