Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2621229..2622817 Replicon chromosome
Accession NZ_LR890665
Organism Klebsiella pneumoniae isolate INF065-sc-2279980

Toxin (Protein)


Gene name hipA Uniprot ID A0A486JB51
Locus tag JMX32_RS12795 Protein ID WP_023316847.1
Coordinates 2621229..2622551 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX32_RS12800 Protein ID WP_002904790.1
Coordinates 2622551..2622817 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX32_RS12780 2616285..2618786 + 2502 WP_087830459.1 fimbrial biogenesis outer membrane usher protein -
JMX32_RS12785 2618774..2619778 + 1005 WP_087830460.1 type 1 fimbrial protein -
JMX32_RS12790 2619920..2621212 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX32_RS12795 2621229..2622551 - 1323 WP_023316847.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX32_RS12800 2622551..2622817 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX32_RS12805 2623082..2623408 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX32_RS12810 2623405..2623905 - 501 WP_023280064.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX32_RS12815 2623883..2625262 - 1380 WP_004184021.1 purine permease -
JMX32_RS12820 2625608..2626762 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMX32_RS12825 2626743..2627666 - 924 WP_201531842.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T291767 WP_023316847.1 NZ_LR890665:c2622551-2621229 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291767 WP_002904790.1 NZ_LR890665:c2622817-2622551 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486JB51

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References