Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206423..207162 Replicon chromosome
Accession NZ_LR890665
Organism Klebsiella pneumoniae isolate INF065-sc-2279980

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMX32_RS01000 Protein ID WP_021312536.1
Coordinates 206677..207162 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMX32_RS00995 Protein ID WP_003026799.1
Coordinates 206423..206689 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX32_RS00980 201926..203995 + 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -
JMX32_RS00985 204292..205661 + 1370 WP_087830479.1 IS3 family transposase -
JMX32_RS00990 205862..206290 + 429 WP_004901287.1 GFA family protein -
JMX32_RS00995 206423..206689 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMX32_RS01000 206677..207162 + 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
JMX32_RS01005 207506..207658 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
JMX32_RS01010 207960..209579 + 1620 WP_032415799.1 ATP-binding cassette domain-containing protein -
JMX32_RS01015 209678..209890 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JMX32_RS01020 210143..210433 - 291 WP_002921931.1 HTH-type transcriptional regulator -
JMX32_RS01025 210679..212034 - 1356 WP_064179508.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 204936..205661 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T291759 WP_021312536.1 NZ_LR890665:206677-207162 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291759 WP_003026799.1 NZ_LR890665:206423-206689 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References