Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 37536..38272 Replicon plasmid 3
Accession NZ_LR890659
Organism Serratia marcescens isolate MSB1_9C-sc-2280320

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag JMX15_RS27790 Protein ID WP_004098919.1
Coordinates 37536..38018 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A2J5Q9C0
Locus tag JMX15_RS27795 Protein ID WP_004098921.1
Coordinates 38006..38272 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX15_RS27775 34996..35775 - 780 WP_004118708.1 DUF1837 domain-containing protein -
JMX15_RS27780 35851..36654 - 804 WP_032724439.1 TIGR02391 family protein -
JMX15_RS27785 36676..37155 - 480 Protein_37 hypothetical protein -
JMX15_RS27790 37536..38018 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
JMX15_RS27795 38006..38272 - 267 WP_004098921.1 DUF1778 domain-containing protein Antitoxin
JMX15_RS27800 38448..38702 - 255 WP_004118702.1 hypothetical protein -
JMX15_RS27805 38778..39035 - 258 WP_004098928.1 hypothetical protein -
JMX15_RS27810 39084..39287 - 204 WP_004098931.1 hemolysin expression modulator Hha -
JMX15_RS27815 39318..39650 - 333 WP_201621545.1 hypothetical protein -
JMX15_RS27820 39726..40694 - 969 WP_077254959.1 IS5 family transposase -
JMX15_RS27825 40765..41445 + 681 WP_004118655.1 copper/silver response regulator transcription factor SilR -
JMX15_RS27830 41438..42913 + 1476 WP_004118652.1 copper/silver sensor histidine kinase SilS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - mrkA 1..147079 147079
- flank IS/Tn - - 39726..40694 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T291757 WP_004098919.1 NZ_LR890659:c38018-37536 [Serratia marcescens]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10105.49 Da        Isoelectric Point: 4.5141

>AT291757 WP_004098921.1 NZ_LR890659:c38272-38006 [Serratia marcescens]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEIACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5Q9C0

References