Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4130664..4131320 Replicon chromosome
Accession NZ_LR890657
Organism Serratia marcescens isolate MSB1_9C-sc-2280320

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7DE55
Locus tag JMX15_RS19865 Protein ID WP_047730091.1
Coordinates 4130664..4131053 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag JMX15_RS19870 Protein ID WP_004941563.1
Coordinates 4131057..4131320 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX15_RS19850 4127133..4128563 + 1431 WP_047730094.1 MFS transporter -
JMX15_RS19855 4128560..4129933 + 1374 WP_055312308.1 two-component system sensor histidine kinase BaeS -
JMX15_RS19860 4129943..4130659 + 717 WP_047730092.1 two-component system response regulator BaeR -
JMX15_RS19865 4130664..4131053 - 390 WP_047730091.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX15_RS19870 4131057..4131320 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX15_RS19875 4131659..4131997 + 339 WP_038873760.1 YegP family protein -
JMX15_RS19880 4132299..4133651 + 1353 WP_038873761.1 tRNA 5-hydroxyuridine modification protein YegQ -
JMX15_RS19885 4133801..4134832 - 1032 WP_001395480.1 IS630-like element ISEc33 family transposase -
JMX15_RS19890 4135274..4136179 + 906 WP_038873764.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4133801..4134352 551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14337.57 Da        Isoelectric Point: 7.8794

>T291753 WP_047730091.1 NZ_LR890657:c4131053-4130664 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT291753 WP_004941563.1 NZ_LR890657:c4131320-4131057 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7DE55

Antitoxin

Source ID Structure

References