Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3398310..3398941 Replicon chromosome
Accession NZ_LR890657
Organism Serratia marcescens isolate MSB1_9C-sc-2280320

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P6GW52
Locus tag JMX15_RS16530 Protein ID WP_047730458.1
Coordinates 3398310..3398708 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMX15_RS16535 Protein ID WP_201621361.1
Coordinates 3398708..3398941 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX15_RS16510 3393413..3394228 - 816 WP_055313115.1 5'-nucleotidase, lipoprotein e(P4) family -
JMX15_RS16515 3394557..3394961 - 405 WP_055315478.1 flagellar protein FlhE -
JMX15_RS16520 3394961..3397039 - 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
JMX15_RS16525 3397032..3398183 - 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
JMX15_RS16530 3398310..3398708 - 399 WP_047730458.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX15_RS16535 3398708..3398941 - 234 WP_201621361.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX15_RS16540 3399067..3399711 - 645 WP_004934858.1 protein phosphatase CheZ -
JMX15_RS16545 3399722..3400111 - 390 WP_004934862.1 chemotaxis response regulator CheY -
JMX15_RS16550 3400214..3401263 - 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
JMX15_RS16555 3401263..3402135 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
JMX15_RS16560 3402173..3403789 - 1617 WP_047730456.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14960.14 Da        Isoelectric Point: 7.4664

>T291752 WP_047730458.1 NZ_LR890657:c3398708-3398310 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEVFNRYAGKMVISSITYGELVHGVENSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAVLERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8828.85 Da        Isoelectric Point: 4.7815

>AT291752 WP_201621361.1 NZ_LR890657:c3398941-3398708 [Serratia marcescens]
MALGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLTERAGQHQREREDF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GW52

Antitoxin

Source ID Structure

References