Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1846285..1846880 Replicon chromosome
Accession NZ_LR890657
Organism Serratia marcescens isolate MSB1_9C-sc-2280320

Toxin (Protein)


Gene name hicA Uniprot ID A0A1S6LRI1
Locus tag JMX15_RS08775 Protein ID WP_071605322.1
Coordinates 1846285..1846539 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMX15_RS08780 Protein ID WP_033633573.1
Coordinates 1846539..1846880 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX15_RS08740 1841294..1841596 + 303 WP_055312643.1 hypothetical protein -
JMX15_RS08745 1841660..1841953 + 294 WP_085819519.1 DUF2732 family protein -
JMX15_RS08750 1841953..1842177 + 225 WP_055312639.1 TraR/DksA C4-type zinc finger protein -
JMX15_RS08755 1842300..1842581 + 282 WP_055312638.1 DUF5405 family protein -
JMX15_RS08760 1842578..1844794 + 2217 WP_055312637.1 replication endonuclease -
JMX15_RS08765 1844833..1845057 + 225 WP_055312636.1 hypothetical protein -
JMX15_RS08770 1845278..1845763 + 486 WP_055312635.1 GNAT family N-acetyltransferase -
JMX15_RS08775 1846285..1846539 + 255 WP_071605322.1 type II toxin-antitoxin system HicA family toxin Toxin
JMX15_RS08780 1846539..1846880 + 342 WP_033633573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMX15_RS08785 1846925..1847959 - 1035 WP_055312634.1 phage portal protein -
JMX15_RS08790 1847959..1849731 - 1773 WP_055312633.1 terminase ATPase subunit family protein -
JMX15_RS08795 1849874..1850689 + 816 WP_055312632.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1832184..1889892 57708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9495.97 Da        Isoelectric Point: 11.1073

>T291747 WP_071605322.1 NZ_LR890657:1846285-1846539 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Download         Length: 255 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12399.90 Da        Isoelectric Point: 4.5789

>AT291747 WP_033633573.1 NZ_LR890657:1846539-1846880 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S6LRI1

Antitoxin

Source ID Structure

References