Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 469501..470072 Replicon chromosome
Accession NZ_LR890657
Organism Serratia marcescens isolate MSB1_9C-sc-2280320

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3SNA4
Locus tag JMX15_RS02175 Protein ID WP_038879053.1
Coordinates 469797..470072 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag JMX15_RS02170 Protein ID WP_013811307.1
Coordinates 469501..469788 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX15_RS02145 465270..466355 - 1086 WP_033636846.1 carbon-phosphorus lyase complex subunit PhnI -
JMX15_RS02150 466355..466936 - 582 WP_055312194.1 phosphonate C-P lyase system protein PhnH -
JMX15_RS02155 466940..467383 - 444 WP_019453314.1 phosphonate C-P lyase system protein PhnG -
JMX15_RS02160 467384..468112 - 729 WP_015376439.1 phosphonate metabolism transcriptional regulator PhnF -
JMX15_RS02165 468340..469395 + 1056 WP_055312195.1 permease -
JMX15_RS02170 469501..469788 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX15_RS02175 469797..470072 + 276 WP_038879053.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JMX15_RS02180 470078..470542 - 465 WP_055312196.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX15_RS02185 470711..472849 - 2139 WP_055312197.1 anaerobic ribonucleoside-triphosphate reductase -
JMX15_RS02190 473094..474008 - 915 WP_048232521.1 LysR family transcriptional regulator -
JMX15_RS02195 474115..474639 + 525 WP_047729213.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.52 Da        Isoelectric Point: 9.5103

>T291745 WP_038879053.1 NZ_LR890657:469797-470072 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT291745 WP_013811307.1 NZ_LR890657:469501-469788 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3SNA4

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References