Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 181662..182287 Replicon plasmid 2
Accession NZ_LR890652
Organism Escherichia coli isolate MINF_2E-sc-2280463

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW95_RS24885 Protein ID WP_000911313.1
Coordinates 181889..182287 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag JMW95_RS24880 Protein ID WP_000450520.1
Coordinates 181662..181889 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW95_RS24880 181662..181889 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
JMW95_RS24885 181889..182287 + 399 WP_000911313.1 tRNA(fMet)-specific endonuclease VapC Toxin
JMW95_RS24890 182296..184521 - 2226 WP_064237182.1 type IV conjugative transfer system coupling protein TraD -
JMW95_RS24895 184774..185505 - 732 WP_023565183.1 complement resistance protein TraT -
JMW95_RS24900 185537..186034 - 498 WP_000605858.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / blaCTX-M-14 iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..207369 207369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T291736 WP_000911313.1 NZ_LR890652:181889-182287 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT291736 WP_000450520.1 NZ_LR890652:181662-181889 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References