Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2473913..2475009 Replicon chromosome
Accession NZ_LR890651
Organism Escherichia coli isolate MINF_2E-sc-2280463

Toxin (Protein)


Gene name hipA Uniprot ID A0A8S7TJ53
Locus tag JMW95_RS12190 Protein ID WP_063112742.1
Coordinates 2474179..2475009 (+) Length 277 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW95_RS12185 Protein ID WP_001296726.1
Coordinates 2473913..2474179 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW95_RS12185 2473913..2474179 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW95_RS12190 2474179..2475009 + 831 WP_063112742.1 HipA N-terminal domain-containing protein Toxin
JMW95_RS12195 2475321..2475529 + 209 Protein_2387 helix-turn-helix transcriptional regulator -
JMW95_RS12200 2475961..2476524 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
JMW95_RS12205 2476884..2477594 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2473913..2489508 15595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(115-237)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 277 a.a.        Molecular weight: 31181.99 Da        Isoelectric Point: 10.0235

>T291717 WP_063112742.1 NZ_LR890651:2474179-2475009 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 831 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT291717 WP_001296726.1 NZ_LR890651:2473913-2474179 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References