Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 848043..848697 Replicon chromosome
Accession NZ_LR890651
Organism Escherichia coli isolate MINF_2E-sc-2280463

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag JMW95_RS04105 Protein ID WP_063112724.1
Coordinates 848290..848697 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JMW95_RS04100 Protein ID WP_000354046.1
Coordinates 848043..848309 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW95_RS04075 843331..844074 + 744 WP_000951964.1 SDR family oxidoreductase -
JMW95_RS04080 844131..845564 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
JMW95_RS04085 845609..845920 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
JMW95_RS04090 846084..846743 + 660 WP_000250274.1 hemolysin III family protein -
JMW95_RS04095 846820..847800 - 981 WP_001472148.1 tRNA-modifying protein YgfZ -
JMW95_RS04100 848043..848309 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JMW95_RS04105 848290..848697 + 408 WP_063112724.1 protein YgfX Toxin
JMW95_RS04110 848737..849258 - 522 WP_001055874.1 flavodoxin FldB -
JMW95_RS04115 849370..850266 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JMW95_RS04120 850291..851001 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW95_RS04125 851007..852740 + 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16082.04 Da        Isoelectric Point: 11.2511

>T291709 WP_063112724.1 NZ_LR890651:848290-848697 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLFHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT291709 WP_000354046.1 NZ_LR890651:848043-848309 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References