Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 81563..82473 Replicon plasmid 2
Accession NZ_LR890649
Organism Klebsiella pneumoniae isolate INF266-sc-2280182

Toxin (Protein)


Gene name - Uniprot ID A0A2A5MBW7
Locus tag JMW87_RS26445 Protein ID WP_023329005.1
Coordinates 81563..82033 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JMW87_RS26450 Protein ID WP_023329004.1
Coordinates 82030..82473 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW87_RS26420 77254..78222 - 969 WP_072206835.1 IS5 family transposase -
JMW87_RS26425 78510..78758 + 249 WP_004187025.1 plasmid stabilization protein -
JMW87_RS26430 78748..79032 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin -
JMW87_RS26435 79048..80391 - 1344 WP_032738442.1 ISNCY family transposase -
JMW87_RS26440 81193..81452 + 260 Protein_90 hypothetical protein -
JMW87_RS26445 81563..82033 - 471 WP_023329005.1 RES family NAD+ phosphorylase Toxin
JMW87_RS26450 82030..82473 - 444 WP_023329004.1 DUF2384 domain-containing protein Antitoxin
JMW87_RS26455 82595..83282 - 688 Protein_93 DUF4113 domain-containing protein -
JMW87_RS26460 83443..84438 - 996 WP_032738441.1 DUF2891 domain-containing protein -
JMW87_RS26465 84448..85434 - 987 Protein_95 DUF979 domain-containing protein -
JMW87_RS26470 85431..86152 - 722 Protein_96 DUF969 domain-containing protein -
JMW87_RS26475 86351..86689 + 339 WP_032738440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..195420 195420
- flank IS/Tn - - 77254..78222 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17459.70 Da        Isoelectric Point: 4.4829

>T291706 WP_023329005.1 NZ_LR890649:c82033-81563 [Klebsiella pneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16477.82 Da        Isoelectric Point: 10.2498

>AT291706 WP_023329004.1 NZ_LR890649:c82473-82030 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADSVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBW7

Antitoxin

Source ID Structure

References