291705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 78510..79032 Replicon plasmid 2
Accession NZ_LR890649
Organism Klebsiella pneumoniae isolate INF266-sc-2280182

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMW87_RS26430 Protein ID WP_004187019.1
Coordinates 78748..79032 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMW87_RS26425 Protein ID WP_004187025.1
Coordinates 78510..78758 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW87_RS26405 74364..74921 - 558 WP_023329012.1 HutD family protein -
JMW87_RS26410 74918..75679 - 762 WP_023329011.1 histidine utilization repressor -
JMW87_RS26415 75782..77149 + 1368 WP_023329010.1 formimidoylglutamate deiminase -
JMW87_RS26420 77254..78222 - 969 WP_072206835.1 IS5 family transposase -
JMW87_RS26425 78510..78758 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMW87_RS26430 78748..79032 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW87_RS26435 79048..80391 - 1344 WP_032738442.1 ISNCY family transposase -
JMW87_RS26440 81193..81452 + 260 Protein_90 hypothetical protein -
JMW87_RS26445 81563..82033 - 471 WP_023329005.1 RES family NAD+ phosphorylase -
JMW87_RS26450 82030..82473 - 444 WP_023329004.1 DUF2384 domain-containing protein -
JMW87_RS26455 82595..83282 - 688 Protein_93 DUF4113 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..195420 195420
- flank IS/Tn - - 77254..78222 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T291705 WP_004187019.1 NZ_LR890649:78748-79032 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT291705 WP_004187025.1 NZ_LR890649:78510-78758 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References