Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 61535..62271 Replicon plasmid 2
Accession NZ_LR890649
Organism Klebsiella pneumoniae isolate INF266-sc-2280182

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JMW87_RS26335 Protein ID WP_023329018.1
Coordinates 61535..62017 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW87_RS26340 Protein ID WP_003026799.1
Coordinates 62005..62271 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW87_RS26315 56813..57631 + 819 WP_023307220.1 abortive infection family protein -
JMW87_RS26320 57702..59045 - 1344 WP_077263966.1 ISNCY family transposase -
JMW87_RS26325 59271..59903 + 633 WP_001567369.1 hypothetical protein -
JMW87_RS26330 59932..61335 - 1404 WP_001272054.1 ISNCY-like element ISKpn21 family transposase -
JMW87_RS26335 61535..62017 - 483 WP_023329018.1 GNAT family N-acetyltransferase Toxin
JMW87_RS26340 62005..62271 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMW87_RS26345 63375..63554 + 180 Protein_71 transposase -
JMW87_RS26350 63521..63655 + 135 WP_109241503.1 integrase core domain-containing protein -
JMW87_RS26355 63807..64616 - 810 WP_023329017.1 N-formylglutamate deformylase -
JMW87_RS26360 64609..65817 - 1209 WP_023329016.1 imidazolonepropionase -
JMW87_RS26365 65829..67223 - 1395 WP_032738443.1 cytosine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..195420 195420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17255.84 Da        Isoelectric Point: 7.8840

>T291704 WP_023329018.1 NZ_LR890649:c62017-61535 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAEGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291704 WP_003026799.1 NZ_LR890649:c62271-62005 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References